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达芦那韦Darunavir

中文名Chinese name:达芦那韦Darunavir
外文名Foreign name:Darunavir
分子式Molecular formula:C27H37N3O7S
分子量Molecular weight:547.66400
CAS号CAS Number:206361-99-1
达芦那韦是一种HIV-1蛋白酶抑制剂,选择性抑制病毒感染细胞中HIV编码的Gag-Pol多蛋白的裂解,从而阻止成熟的感染性病毒颗粒的形成。Darunavir is an HIV-1 protease inhibitor that selectively inhibits the cleavage of HIV encoded gag pol polyproteins in HIV infected cells, thus preventing the formation of mature infectious virus particles.   
达芦那韦与HIV-1蛋白酶紧密结合,Kp值为4.5×10-12M。达芦那韦对于蛋白酶抑制剂耐药相关的突变(RAM)具有一定的疗效,但达芦那韦对目前检测到的13种人体细胞蛋白酶没有抑制作用。Dalunavir was tightly bound to HIV-1 protease with a KP value of 4.5 × 10-12m. However, dalunavir has no inhibitory effect on 13 human cell proteases.
储存/保存方法Storage / preservation method:store at -20℃
别名Alias:地瑞那韦Darunavir;地瑞拉韦; Darunavir
外观Appearance:白色或类白色固体white or white like solid
可溶性/溶解性Solubility / solubility:Ethanol : 35 mg/mL (78.14 mM)
生物活性靶点Bioactive target:HIV Protease